Research

Stem Cells in Orthopedics

The use of stem cells in orthopedics has gained recognition and popularity for a variety of clinical problems. The important source of stem cells for clinical use is from the bone marrow and the adipose tissue. The main indication for stem cells in orthopedics includes nonunion of the fractures, avascular necrosis (AVN), cartilage damage, and tendinopathies.

Implant Strategies in Orthopedics

Orthopedic implant technology is carrying on advancing each day and offers different treatments with different materials and technologies. In this chapter, the uses of implants in orthopedics and new approaches like smart implants or surface modifications and stem cell applications are mentioned. Besides, regulations for orthopedic implants and the future of the implant sector are explained from the perspective of new and emerging technologies.

Regenerative medicine in orthopedics using cells, scaffold, and microRNA

In our studies, use of these cells combined with a cell-delivery system, miRNA, scaffold, and cytokines has led to effective regeneration of musculoskeletal tissues including cartilage, bone, ligaments, muscle, peripheral nerves, and spinal cord. The current and future objective is more effective and less invasive cell-based therapy with spatial control of transplanted cells by use of an external magnetic force. Analysis of efficiency, safety, and the mechanism of tissue regeneration by cells, scaffold, and miRNA will lead to more promising regenerative medicine, involving the development of a new generation of therapy. This review will focus on our regenerative medicine research, which focuses on clinical application of cells, scaffold, and miRNA.